肠道微生物组与儿童细菌性肺炎

Intestinal microbiome and bacterial pneumonia in children

肠道菌群是寄居在人体肠道内的微生物群落的总称,它可以通过增加肠道外T细胞的数量、产生短链脂肪酸、增强口服耐受及控制炎症等途径影响全身免疫系统。肠道菌群失调可能参与多种疾病的发生过程。动物实验发现,正常肠道菌群有利于增加机体抵抗细菌性肺炎的肺部免疫,这种肠道和肺部相互影响的作用被称为"肠-肺轴(gut-lung axis)"。虽然,关于"肠-肺轴"的具体机制仍待进一步研究,但"肠-肺轴"的提出对于采用微生态制剂、粪菌移植调节或恢复肠道菌群进而治疗肺部疾病提供了新思路。

Intestinal microbiota is a general term of microbial communities that reside in the human intestine,which can affect the systemic immune system by expansion of extra-intestinal T cell populations,production of short-chain fatty acids,development of oral tolerance,and control of inflammation.Intestinal intestinal dysbiosis may be involved in a variety of disease processes. Animal experiments have found that normal intestinal flora is beneficial to increase lung immunity against bacterial pneumonia. This interaction between intestinal and lung is known as ＂Gut-Lung axis＂. Although the specific mechanism of the ＂Gut-Lung axis＂ is still poorly undertood,the proposal of which provides new insights into the use of microecologic products or fecal bacteria transplantation to regulate or restore the intestinal flora and then to treat lung diseases.