中晚期鼻咽癌放化疗前后中医证型与VEGF的相关性研究

Correlation Study on the TCM Syndromes and VEGF in Moderate-Advanced Nasopharyngeal Carcinoma before and after Chemoradiotherapy

目的研究中晚期鼻咽癌患者同期放化疗前后中医证型和VEGF的相关性。方法对初入院中晚期鼻咽癌患者进行中医辨证分析和VEGF表达检测,对完成放化疗的108例患者再进行中医辨证。分析比较108例患者放化疗前后的中医证型,计算不同证型的VEGF阳性率。结果放化疗前中医证型以瘀血阻络型和痰浊内阻型为主,痰浊内阻证型患者肿瘤组织VEGF阳性率最高;放化疗后阴虚气滞、气血两亏证型明显增多,痰瘀气滞证型患者肿瘤组织VEGF阳性率最高。结论中晚期鼻咽癌患者同期放化疗前中医证型与VEGF表达有一定的相关性,其科学性有待进一步研究。

Objective To study the correlation between TCM syndromes and VEGF in moderate-advanced nasopharyngeal carcinoma before and after concurrent chemoradiotherapy. Methods Newly admitted patients with moderate-advanced nasopharyngeal carcinoma received TCM syndrome differentiation analysis and VEGF expression detection. 108 cases of patients received TCM syndrome differentiation analysis again after completing concurrent chemoradiotherapy. TCM syndromes of 108 cases of patients before and after chemoradiontherapy were analyzed and compared. The VEGF positive rates of different TCM syndromes were counted. Results Before chemoradiontherapy, the main TCM syndromes were static blood blocking collaterals and phlegm retention. Patients with phlegm retention had the highest VEGF positive rate of tumor tissues. After chemoradiontherapy, the syndromes of yin dificiency qi depression significantly increased. Patients with phlegm retention Qi stagnation syndrome had the highest VEGF rate of tumor tissues. Conclusions TCM syndromes in moderate-advanced nasopharyngeal carcinoma before concurrent chemoradiotherapy are related to VEGF expression, and further research about its scientificalness is needed.