绿原酸抗肿瘤作用及机制研究进展

Research Progress in Anti-tumor and Mechanism of Chlorogenic Acid

绿原酸是植物经光合作用合成的一种苯丙素类似物,在多种中药材中的含量高,是其主要的药理活性成分,其药理作用广泛,在食品、医药和化工等领域均有应用,其分子结构中含有酯键、不饱和双键等多种不稳定结构,容易被氧化、见光、受热都容易使其活性丧失,在酸性环境中比较稳定。有抗癌、降血脂、抗氧化、降血糖、抗紫外光与辐射、抗菌、免疫调节等作用,随着科技的进步、研究的深入,其抗肿瘤活性逐渐被重视。绿原酸具有抗肿瘤作用,其对肺癌、肝癌、乳腺癌、鼻咽癌、结肠癌、宫颈癌、胃癌、口腔癌、白血病、视网膜母细胞瘤、黑色素瘤、皮肤癌等发病率较高的肿瘤均表现出较好的防治效果。绿原酸的抗肿瘤作用机制可能与其阻滞细胞生长周期、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤血管生成、抑制转移、抑制端粒酶活性、调节免疫、逆转肿瘤细胞多药耐药等作用有关。本文以＂绿原酸＂＂抗肿瘤＂＂Chlorogenic acid＂＂antitumor＂等为关键词,组合搜索1999年1月至2018年1月PubM ed,维普,中国知网,万方等数据库中相关的文献,共搜索到110余篇相关文献,其中真正有效的文献51篇,本课题组对其有效文献中涉及的抗肿瘤作用及机制进行综述,希望能为绿原酸的抗肿瘤活性深入研究提供参考。

Chlorogenic acid is a kind of styrene acrylic analogues synthesized through photosynthesis,with high content in many kinds of Chinese medicinal materials as the main pharmacological active ingredient. Due to its extensive pharmacological effect,it is widely used in areas such as food,medicine and chemical industry.The molecular structure contains ester bond and unsaturated double bond,and other unstable structures,easy to oxidation,and it will lose its activity under light and heating conditions,but it is stable in acidic environment. It has anticancer, hypolipidemic, antioxidant, hypoglycemic, ultraviolet and radiation resistant, antibacterial,immune regulation and other functions. With the progress of science and technology and the deepening of the research,more focus has been put on anti-tumor activity. Chlorogenic acid has anti-tumor effect,showing better prevention and treatment effect on lung cancer,liver cancer,breast cancer,nasopharyngeal carcinoma,colon cancer,cervical cancer,stomach cancer,oral cancer,leukemia,retinoblastoma,melanoma,skin cancer and other tumors with higher incidence. The mechanism of chlorogenic acid may be related to blocking cell growth cycle,inhibiting tumor cell proliferation,inducing tumor cell apoptosis and inhibiting tumor angiogenesis,inhibiting metastasis,inhibiting telomerase activity,immune regulation,reversing multi-drug resistance of tumor cells,and so on. By taking chlorogenic acid,antitumor,etc as keywords,we searched related papers in Pubmed,VIP,CNKI and other databases between January 1999 and January 2018,and more than 110 related documents were obtained,but only 51 of them were effective. We reviewed the anti-tumor function and mechanism in effective papers,hoping to provide the reference for the deep research of anti-tumor activity of Chlorogenic acid.