945例PCOS不孕妇女临床与代谢特征分析

Analysis of clinical and metabolic characteristics in 945 infertility women with PCOS

目的观察多囊卵巢综合征(PCOS)不孕妇女的临床及代谢特征。方法对945例多囊卵巢综合征不孕患者的临床、内分泌及代谢指标进行分析。结果 945例患者中肥胖发生率28.89%,22.96%为中心型肥胖。胰岛素抵抗的发生率为46.67%,肥胖组胰岛素抵抗的发生率(61.54%)明显高于非肥胖组(40.62%),差异有显著性;高胰岛素血症的发生率为26.67%,肥胖组高胰岛素血症的发生率(35.89%)明显高于非肥胖组(21.87%),差异有显著性。血脂异常发生率为48.15%,肥胖较非肥胖组甘油三酯明显升高,差异有显著性。总胆固醇、高密度脂蛋白、低密度脂蛋白及空腹血糖两组之间没有明显差异。肥胖组LH水平较非肥胖组低,差异有显著性,卵泡生成素(FSH)、黄体生成素(LH)、LH/FSH、睾酮(T)、催乳激素(PRL)、雌二醇(E2)两组之间无显著性差异。结论PCOS不孕患者除内分泌紊乱外,部分伴随糖、脂代谢的异常,肥胖者较非肥胖者更明显,因此综合防治有重要的临床意义。

Objective To analyze the clinical and metabolic characteristics of infertility women with PCOS. Methods The items of clinical endocrine and metabolic index of 945 cases with PCOS suffered from infertility were analysed. Results Of the 945 cases,obesity ones accounted for 28. 89%,with abdominal obesity 22. 96%. Insulin resistance cases occupied 46. 67%,with the incidence rate of obesity group（ 61.54%） obviously higher than that of non-obesity one（ 40. 62%）,with a significant difference. Hyperinsulinemia cases take up 26. 67%,of which the incidence of obesity group（ 35. 89%） was apparently higher than non-obesity group（ 21. 87%）,with a significant difference. The rate of blood fat abnormality was 48. 15%,with triglyceride of the obesity group greatly higher than non-obesity one,with a significant difference. There was no significant difference between the two groups in terms of TC,HDLC,LDLC and FBG. The LH level of obesity group was lower than nonobesity one,with a significant difference. There was no significant difference between the two groups of FSH,LH,LH/FSH,T,PRL and E2. Conclusion Infertility patients with PCOS are usually accompanied with endocrine disorder,some with abnormal metabolism of glucose and lipid,which is more severe in the obese. Comprehensive prevention is of great clinical significance.