母体脂代谢与胎儿生长发育

Maternal lipid metabolism and fetal growth

妊娠期母体脂代谢会发生变化以保证胎儿生长发育的需要,母体在妊娠早中期脂肪合成增加,在妊娠晚期脂肪水解增加并出现生理性的高脂血症。脂代谢紊乱影响胎儿的生长发育,导致巨大儿或胎儿生长受限;脂代谢紊乱对后代产生的影响可以持续到成年后,即使出生后经过调节,也不能完全消除。

Changes in lipid metabolism during gestation is essential for fetal development.During early and middle pregnancy,there is an increased accumulation of fat synthesis in the mother,which switches to an increased lipolysis and maternal hyperlipidemia during the last trimester.Dyslipidemia affects fetal development which can cause macrosomia or fetal growth retardation.The effect of dyslipidemia on offspring can persist to their adult stage,even if the diet style is adjusted after birth.