高频超声评价2型糖尿病患者股动脉血管重构及其与中性粒细胞/淋巴细胞比值的相关性

Evaluation of remodeling of femoral artery and its correlation with neutrophil to lymphocyte ratio in patients of type 2 diabetes mellitus by high-frequency ultrasonography

目的:应用高频超声评价2型糖尿病患者(T2DM)股动脉血管重构及其与中性粒细胞/淋巴细胞比值(NLR)的相关性。方法:将88例T2DM患者按病程分为2组:病程小于10年为B组(48例);大于10年为C组(40例);另有36例为正常对照组(A组);应用高频超声测量股动脉内-中膜厚度(IMT);如有斑块形成,通过测量此处血管总面积(TVA)、管腔面积(LA)、重构指数(RI)判定血管重构类型;获得血清NLR。结果:各组之间股动脉IMT、NLR和RI比较:IMT和NLR:B、C组均大于A组,C组大于B组,差异均具有统计学意义(P均<0.05)。RI:B组大于A组(P<0.05),C组小于B组(P<0.05)。各组之间股动脉血管重构发生率及重构类型比较:重构发生率比较:B、C组大于A组(P均<0.05),C组大于B组(P<0.05);重构类型比较:B组正重构发生率高于A、C组(P均<0.05),C组负重构发生率高于A、B组(P均<0.05)。各组内重构类型比较:A组以血管无重构为主,B组血管正重构发生率高于负重构发生率,C组血管负重构发生率高于正重构发生率。IMT与NLR呈正相关关系(r=0.56,P<0.05)。结论:高频超声可以精确的评价T2DM患者股动脉粥样硬化血管重构以及与NLR的关系,具有重要的临床意义。

Objective： To evaluate remodeling of the femoral artery and its correlation with neutrophil to lymphocyte ratio （NLR） in patients of type 2 diabetes mellitus（T2DM） by high-frequency ultrasound. Methods： Eighty-eight patients with T2DM were divided into group B（48 cases, the course≤10 years） and group C（40 cases, the course〉10 years）. 36 healthy volunteers were recruited as the control group（group A）. The intimal medial thickness（IMT）, total vessel area（TVA）, lumen area（LA） were measured and vascular remodeling types were determined. NLR was calculated and obtained from the peripheral blood routine examination. Results： IMT and NLR of the femoral in group B and C were higher, has significant difference. And IMT and NLR of the femoral in group C were higher than that in group B（all P〈0.05）. RI in group B was higher than that of group A （P〈0.05）. RI in group C was lower than that of group B（P〈0.05）. The vascular remodeling rates in group B and C were higher than that in group A（all P〈0.05）, and in group C was higher than that in group B（P〈0.05）. The positive remodeling rate of group B was higher than that of other two groups, and the difference were significant. The rate of negative remodeling in group C was higher than that of group A and B （all P〈0.05）. Vessels without remodeling was predominant in group A. The rate of negative remodeling was higher than the rate of positive remodeling in group C. The rate of positive remodeling was higher than the rate of negative remodeling in group B. IMT was positively correlative with NLR（r=0.56, P〈0.05）. Conclusion： The atherosclerosis, vascular remodeling of the femoral artery and the relationship with NLR in the patients of T2DM can be evaluated conveniently and accurately by high-frequency ultrasonography with an important clinical value.