应用FibroTouch技术评价2型糖尿病患者肝脏脂肪变和纤维化程度及二者相关性

Evaluation of liver steatosis and fibrosis in patients of type 2 diabetes mellitus and correlation between liver steatosis and fibrosis by FibroTouch technique

目的:应用FibroTouch技术评价2型糖尿病(T2DM)患者肝脏脂肪变和纤维化程度及二者相关性。方法:将92例T2DM患者按病程分为两组:病程>10年(A组)46例;病程≤10年(B组)46例,正常对照组(C组)46例。应用FibroTouch技术对肝脏脂肪衰减参数和肝脏硬度值进行检测,获得肝脏脂肪衰减参数和肝脏硬度值。结果:A组和B组肝脏脂肪衰减参数和肝脏硬度值均明显大于C组(P均<0.05);A组肝脏脂肪衰减参数小于B组(P<0.05);A组肝脏硬度值大于B组(P<0.05)。A组、B组脂肪衰减的程度较C组增加(P均<0.05);A组脂肪衰减的程度较B组减低(P<0.05);A组、B组肝脏硬度的程度较C组增加(P均<0.05),A组肝脏硬度的程度较B组增加(P<0.05)。T2DM患者肝脏脂肪变和纤维化程度之间呈明显负相关性(r=-0.81,P<0.05)。结论:FibroTouch技术可以无创、方便、客观地评价T2DM患者肝脏脂肪变和纤维化程度,具有重要的临床价值。

Objective： To evaluate the extent of liver steatosis and fibrosis in patients of type 2 diabetes mellitus（T2DM） and correlation between liver steatosis and fibrosis by FibroTouch technique. Methods： Ninety-two cases of T2DM patients were enrolled and divided into group A （46 cases, diabetic duration〉10 years） and group B （46 cases, diabetic duration≤10 years）. Forty-six healthy subjects were enrolled as controls （group C）. FibroTouch technique was used to measure the liver fat attenuation parameter （FAP） and liver stiffness t （LSM）. Results： The FAP and LSM of group A and group B were significantly larger than those of group C （all of P〈0.05）; the FAP of group A was smaller than that of group B and the LSM of group A was larger than that of group B（all P〈0.05）. The degree of liver steatosis increased in group A and group B compared with that of group C（all of P〈0.05）, and the degree of liver steatosis decreased in group A compared with that of group B（P〈0.05）; The degree of liver stiffness increased in group A and group B compared with that of group C （all of P〈0.05）, and the degree of liver stiffness increased in group A compared with that of group B（P〈0.05）. There was a negative correlation be- tween liver fibrosis and steatosis （r=-0.81, P〈0.05）. Conclusion： The fibrosis and steatosis of the liver in T2DM patients can be evaluated non-invasively, conveniently and objectively by FibroTouch technique, which has an important clinical value.