产前超声对11～14孕周胎儿颅脑畸形的诊断价值

The diagnostic value of prenatal ultrasound for fetal brain malformations during 11～14 weeks of gestation

目的:探讨产前超声在诊断11~14孕周胎儿颅脑畸形中的临床应用价值。方法:回顾性分析产前超声检查发现的71例11~14孕周颅脑畸形胎儿的声像图特征、临床资料及随访结果。结果 :63例超声诊断的颅脑畸形中无脑畸形17例,露脑畸形21例,脑膜(脑)膨出8例,全前脑17例。11~14孕周超声检查未发现的颅脑畸形8例,其中6例脑积水,1例全前脑畸形,1例脑膜膨出。63例11~14孕周颅脑畸形中合并其他系统或器官异常25例,占39.7%(23/63),其中17例合并多发畸形。结论:产前超声对11~14孕周胎儿颅脑畸形有较高的诊断价值,为临床早期干预提供重要依据。

Objective： To investigate the prenatal ultrasound of the diagnosis of value of the clinical application of fetal brain malformations at 11-14 weeks of gestation. Methods： Seventy-one cases of brain malformation fetus as the research object from January 2012 to May 2017 in Southwest Hospital, and uhrasonographic characteristics, clinical data and follow-up results of fetuses with brain malformations were retrospectively analyzed. Results： Among 63 cases of brain malformations diagnosed by ultrasound, 17 cases were aneneephaly, 21 cases were encephalomegaly, 8 cases were meningoeele and 17 cases were whole forebrain. Eight cases of brain malformations were not detected by nltrasonography during 11-14 weeks of preg- nancy, including 6 cases of hydrocephalus, 1 cases of complete forebrain deformities, and 1 cases of meningoele. Among 63 cases of 11-14 gestational weeks, 25 cases （39.7%） were complicated with other system or organ abnormalities, of which 17 cases were complicated with multiple malformations. Conclusion： Prenatal ultrasound has a high diagnostic value for fetal brain abnormalities at 11-14 gestational weeks, by providing important evidence for early clinical intervention.