煤工尘肺壹期患者血清SP-A和SP-D水平及意义

Serum levels of SP-A and SP-D in stage Ⅰ coal workers' pneumoconiosis and their significance

目的探讨煤工尘肺(CWP)壹期患者血清中表面活性蛋白(SP)A和SP-D水平变化及其意义。方法采用随机数表抽样法,以88名CWP壹期患者为CWP组,以50名与CWP组具备相同粉尘接触条件的健康井下接尘矿工为接尘组,以38名非粉尘接触井上人员为对照组。采用酶联免疫吸附法检测3组人群血清中SP-A和SP-D水平。结果 CWP组和接尘组人群血清中SP-A和SP-D水平均高于对照组(P<0.05);CWP组人群血清中SP-D水平高于接尘组(P<0.01)。CWP组吸烟亚组人群血清中SP-D水平低于CWP组非吸烟亚组(P<0.05)。结论血清中SP-A和SP-D水平异常与CWP壹期发生发展有关;吸烟可影响CWP壹期患者血清中SP-D水平。

Objective To explore the changes of serum levels and significance of surfactant protein（ SP） A and SP-D in patients with stage Ⅰ coal workers＇ pneumoconiosis（ CWP）. Methods A random sampling method was used to select 88 cases of stage Ⅰ CWP patients as the CWP group,50 cases of healthy underground miners with similar dust exposure history as the dust exposure group and 38 cases of ground workers without dust exposure history as the control group. The serum levels of SP-A and SP-D in 3 groups were detected by enzyme-linked immunosorbent assays. Results The levels of serum SP-A and SP-D in the CWP group and the dust exposure group were higher than that of the control group（ P 0. 05）. The serum level of SP-D in the CWP group was higher than that of the dust exposure group（ P 0. 01）. The serum level of SP-D in the smoking CWP subgroup was lower than that of the non-smoking CWP subgroup（ P 0. 05）.Conclusion The abnormal serum levels of SP-A and SP-D were related to the development of stage Ⅰ CWP. Smoking might affect the serum level of SP-D in stage Ⅰ CWP patients.