长链非编码RNA与类风湿关节炎研究进展

Research progress in long non-coding RNAs and rheumatoid arthritis

在人类基因组DNA核苷酸序列中,只有不到2%的基因可用于编码蛋白质,其余均为编码能力极低或不具备编码能力的非编码RNA。长链非编码RNAs(lncRNAs)参与了包括细胞增殖、分化、凋亡等生物过程;同时也参与了免疫调节,其在自身免疫病,如系统性红斑狼疮、类风湿关节炎(RA)等疾病中扮演着十分重要的作用。目前报道的lncRNAs在自身免疫性疾病中的功能,仅有很少一部分;且其在自身免疫性疾病中的调控机制尚少见报道。因此,本文就lncRNAs与RA的关系进行综述。

Less than 2% of the nucleotide sequence of human genomic DNA can be used to encode proteins,and the rest are non-coding RNAs with little or no coding capacity. In recent years,long non-coding RNAs（ lncRNAs） have attracted widespread attention. More and more evidence shows that lncRNAs are involved in biological processes including cell proliferation,differentiation,and apoptosis. It is also involved in immune regulation and plays an important role in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis（ RA）. However,so far only a small part of the specific functions of lncRNAs in autoimmune diseases have been elucidated,and their regulatory mechanisms in autoimmune diseases still have many unrecognized places. For lncRNAs,the pathogenic mechanism of RA is rarely reported at present,so it has become a research hotspot in this field in recent years. This article summarizes the research results of lncRNAs and RA in recent years.