栝蒌桂枝汤联合西医疗法治疗癫痫疗效及对脑电图的影响

Effects of Gualou Guizhi Decoction Combined with Western Medicine in the Treatment of Epilepsy and Influence on EEG

目的:探讨栝蒌桂枝汤联合西医常规治疗的疗效及对脑电活动的影响。方法:选取2013年1月至2016年10月武汉钢铁公司第二职工医院收治的癫痫患者108例。按照随机数字表法,随机分为观察组和对照组,每组54例,观察组以栝蒌桂枝汤联合西医治疗,对照组以单纯西医常规治疗。观察2组患者的临床疗效、癫痫发作频次、脑电图、生命质量以及不良反应。结果:观察组临床疗效优于对照组(P<0.05);中药组治疗后不同时间癫痫发作频率均低于对照组(P<0.05);观察组患者治疗后脑电图频段相对功率变化均优于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05);观察组生命质量优于对照组(P<0.05)。结论:栝蒌桂枝汤联合西医疗法对癫痫患者临床疗效肯定,降低不良反应发生率。

Objective： To investigate the curative effect of Chinese herbs combined with conventional western medicine treatment and the effect on the electrical activity of the brain. Methods： A total of 108 patients with epilepsy in our hospital from January2013 to October 2016 were treated. According to random table method,they were randomly divided into treatment group（ Gualou Guizhi Decoction combined with western medicine treatment） and control group（ conventional western medicine therapy）,with 54 cases in each group. The clinical curative effects,the seizure frequency,EEG,quality of life and adverse reactions of two groups were observed. Results： The clinical curative effect of traditional Chinese medicine group was better than the control group（ P 〈0. 05）. The seizure frequency at different time in the traditional Chinese medicine group after treatment was lower than the control group（ P 〈0. 05）. EEG frequency relative power variation in the traditional Chinese medicine group was better than the control group after treatment（ P 〈0. 05）. The occurrence rate of adverse reactions of traditional Chinese medicine group was lower than the control group（ P 〈0. 05）. The quality of life of traditional Chinese medicine group was better than the control group（ P 〈0. 05）.Conclusion： The effects of Gualou Guizhi Decoction combined with western medicine therapy for patients with epilepsy should be affirmed,which can reduce seizure frequency,the incidence of adverse reactions,improve the electrical activity of the brain,improve the life quality of patients.