体检人群幽门螺杆菌感染与超重、肥胖的相关性研究

Association between Helicobacter pylori infection and overweight / obesity among adult health checkup population in China

目的 探讨成人体检人群幽门螺杆菌感染与超重、肥胖的相关性,以期为超重、肥胖的管理提供新的线索.方法 采用横断面研究方法,2016年1—12月在武汉同济医院体检中心进行过13C呼气试验的成人健康体检者,收集其人口学信息、体格测量指标、血生化指标、疾病史等特征,采用多因素分析方法探讨幽门螺杆菌感染与超重、肥胖以及体质指数的相关性.结果 共纳入研究对象27883人,其中男性17585人,女性10298人;年龄为（43.94±11.31）岁;幽门螺杆菌感染阳性率为33.1%.幽门螺杆菌感染阳性者的体质指数为（24.30±3.28）kg/m^2,高于阴性者的体质指数（23.99±3.35）kg/m^2（t=-7.28,P〈0.001）;在调整了年龄、性别、血脂水平、糖尿病和高血压等混杂因素后,幽门螺杆菌感染阳性者的体质指数比阴性者平均高0.120 kg/m^2（95%CI：0.050-0.191,P=0.001）.此外,幽门螺杆菌感染与超重、肥胖的患病风险成独立正相关,OR值（95%CI）为1.09（1.03-1.16）（P=0.004）;在女性体检者中更为明显,OR值（95%CI）为1.19（1.07-1.31）（P=0.001）.结论 成人体检人群幽门螺杆菌感染与超重、肥胖的发生密切相关,通过控制幽门螺杆菌感染对超重、肥胖者进行健康管理是一个值得探索的方向.

Objective To explore the association between Helicobacter pylori （H.pylori） infection and overweight/obesity in a Chinese population. Methods This was a cross-sectional study that included all adult participants who underwent a ^13C-urea breath test at the physical examination center in Tongji Hospital （Wuhan, China） in 2016. Data on demographic characteristics, anthropometric index, biochemical variables, and medical history were collected. Multivariate analyses were performed to assess the relationship between H. pylori infection and overweight/obesity, as well as body mass index （BMI）. Results Of the 27 883 participants included, 17 585 were males and 10 298 were females. They were aged （43.94± 11.31） years. The prevalence rate of H. pylori infection was 33.1%. The BMIs of subjects with and without H. pylori infection were （24.30±3.28） kg/m^2 and （23.99±3.35） kg/m^2, respectively （t=-7.28, P〈0.001）. After adjusting for age, sex, blood lipid levels, diabetes, and hypertension, the BMI of subjects with 14. pylori infection was 0.120 kg/m^2 （95% Ch 0.050-0.191, P=0.001）, which was higher than that of subjects without H. pylori infection. Moreover, H. pylori infection was independently associated with a higher risk of prevalent overweight/obesity, with an odds ratio （OR） of 1.09 （95%CI： 1.03-1.16, P=0.004）. The positive association between H. pylori infection and overweight/obesity was more evident among women, with an OR of 1.19 （95%CI： 1.07-1.31, P=0.001）. Conclusion 14. pylori infection was closely correlated with overweight/ obesity. Control of H. pylori infection may be useful in reducing the heavy disease burden caused by overweight/obesity.