自然杀伤细胞在反复种植失败中的研究进展

Progress of nature killer cells and repeated implantation failure

反复种植失败(RIF)是影响体外受精-胚胎移植(IVF-ET)成功率的重要因素,胚胎种植成功与否与胚胎质量和子宫内膜容受性相关。在月经周期增殖期,子宫内膜细胞功能层有少量自然杀伤(NK)细胞,排卵后NK细胞显著增加,胚胎着床后NK细胞将维持高水平至妊娠早期。蜕膜NK细胞是母-胎界面含量最多的免疫细胞,对胚胎种植、蜕膜血管重铸、胎盘形成、滋养细胞侵袭和妊娠结局都有非常重要的作用。本文就蜕膜NK细胞在胚胎种植过程中发挥作用的研究进展作一综述。

Repeated implantation failure （RIF） is one of the important factor to success rate of in vitro fertilization-embryo transfer （IVF-ET）, the success of embryo implantation is related to the quality of the embryo and the endometrial receptivity. Early in the menstrual cycle, there are a small amount of nature killer （NK） cells in the endometrial cell function layer, they elevate after ovulation, and maintain a high level if the embryo implantated till every pregnancy rate. Decidual NK cells are the most abundant immune cells of maternal- fetal interface, which play an important role in modulating embryo implantation, angiogenesis and vascular remodeling, placentation, trophoblast invasion and pregnancy outcome. Our understanding of this condition is still limited. In this paper, the role of the decidual NK cells and embryo implantation were reviewed.