胰岛素样生长因子2/H19印迹基因在辅助生殖中的研究进展

Progress in the study of insulin-like growth factor 2/H19 imprinting genes in assisted reproduction

我国不孕不育夫妇呈逐年上升的趋势,而辅助生殖技术(assisted reproductive technology,ART)已成为治疗不孕不育的主要方法之一。胰岛素样生长因子(IGF)2/H19基因在配子形成、受精过程、胚胎的早期发育中有着至关重要的作用,而IGF2/H19基因甲基化水平的变化直接影响其基因的表达。ART过程是否会改变IGF2/H19基因甲基化水平,这些基因甲基化水平的改变又是否会影响ART治疗后的妊娠结局。本文就这些问题结合目前的研究现状进行综述。

China＇s infertility couples are increasing year by year, and assisted reproductive technology （ART） has also become one of the main ways to treat infertility couples. Insulin-like growth factor （IGF）2/H19 gene imprinting plays a crucial role in gametogenesis, fertilization, and early development of embryos. Moreover, changes in the methylation level of the IGF2/H19 gene directly affect the expression of its gene. Will the ART process change the methylation level of IGF2/H19 gene？ Futhermore, whether changes in the methylation levels of these genes will affect the pregnancy outcome after ART treatment. This article reviews these issues in conjunction with current research.