中性粒细胞与淋巴细胞比和血小板与淋巴细胞比在布鲁氏杆菌病中的临床价值

Diagnostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in brucellosis

目的 探讨血液参数平均血小板体积（mean platelet volume,MPV）,中性粒细胞与淋巴细胞比（neutrophil to lymphocyte ratio,NLR）,血小板与淋巴细胞比（platelet to lymphocyte ratio,PLR）在布鲁氏杆菌病（简称布病）中的诊断价值.方法 回顾性分析2016年6月至2017年6月在黑龙江省农垦总局总医院确诊的200例布病患者,200名年龄和性别匹配的健康体检患者作为对照组.比较白细胞计数（white blood cell,WBC）,中性粒细胞计数,淋巴细胞计数,血小板计数（platelet,PLT）,血红蛋白（hemo-globin,Hb）及平均血小板体积（mean platelet volume,MPV）,中性粒细胞与淋巴细胞比（neutrophil to lym-phocyte ratio,NLR）,血小板与淋巴细胞比（platelet to lymphocyte ratio,PLR）.同时对部分常见的炎症标记物如红细胞沉降率（erytrocyte sedimentation rate,ESR）、超敏C反应蛋白（hypersensitive C-reactive pro-tein,hs-CRP）,也进行了比较.结果 分析结果显示WBC计数、中性粒细胞计数、Hb和NLR值在患者组与对照组之间存在统计学差异（P〈0.05）.淋巴细胞计数、血小板计数、MPV、PLR在患者组与对照组之间差异没有统计学意义（P〉0.05）.当患者被分为关节炎阳性组和关节炎阴性组时,与对照组比较,NLR在关节炎阳性组更有意义（P=0.009）.Hb在关节炎阳性组和对照组之间也差异有统计学意义（P〈0.05）.此外,我们还发现患者组与对照组ESR、hs-CRP结果差异有统计学意义（P〈0.05）.结论 NLR值可以作为布鲁氏菌病的炎症标志物.NLR在患有布鲁氏病关节炎的患者中更具有价值.

 Objective To investigate diagnostic value of mean platelet volume（MPV）,neutrophil to lymphocyte ratio（NLR）and platelet to lymphocyte ratio（PLR）in brucellosis disease. Methods In this retro-spective study,we reviewed 200 cases of patientswith confirmed brucellosis in the General Hospital of Hei-longjiang Province Land Reclamation Bureau during June 2016 to June 2017,200 healthy people with matched-age and sex were recruited as control group. White blood cell （WBC）count,neutrophil count,lymphocyte count,platelet count,hemoglobin （Hb）,MPV,NLR and PLR were determined. In addition,inflammatory mark-ers such as erytrocyte sedimentation rate（ESR）and hypersensitive C-reactive protein （hs-CRP）were also ana-lyzed. Results WBC count,neutrophil count,Hb and NLR were significantly different between the patient group and the control group（P 〈 0. 05）. There was no significant difference in lymphocyte count,platelet count, MPV and PLR between the patient and control group（P 〉 0. 05）. NLR was more significantly different between patients with arthritis and that without arthritis（P = 0. 009）. The difference of Hb was also significant between patients with arthritis and without arthritis（P 〈 0. 05）. ESR and （hs-CRP）were also different between patients and controls （P 〈 0. 05）. Conclusion NLR can be used as an inflammatory marker for Brucellosis. In addi-tion,NLR is more valuable for the diagnosis of patients with brucella arthritis.