补肾疏肝养血法联合沙利度胺治疗强直性脊柱炎对C-反应蛋白、肿瘤坏死因子-α的影响

The C-reactive protein and tumor necrosis factor-α effects of tonifying kidney, soothing liver and nourishing blood combined thalidomide in the treatment of ankylosing spondylitis

目的 探讨补肾疏肝养血法联合沙利度胺治疗强直性脊柱炎的对C-反应蛋白（C-reactive protein,CRP）和肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）的影响.方法 2011年1月到2017年2月选择在十堰市太和医院诊治的AS患者150例作为研究对象,按照入院顺序,把患者分为观察组与对照组各75例,观察组给予沙利度胺与补肾疏肝养血法治疗,对照组仅给予沙利度胺治疗,两组都治疗并观察3个月.结果 观察组与对照组的总有效率分别为98.7％和88.0％,观察组的总有效率高于对照组（P〈0.05）.观察组与对照组治疗后的夜间痛与脊柱痛目视模拟标尺法（visual analogue scale,VAS）评分都显著低于治疗前（P〈0.05）,同时治疗后观察组的夜间痛与脊柱痛VAS评分也低于对照组（P〈0.05）.观察组与对照组治疗后的强直性脊柱炎功能指数（bath as function index,BASFI）评分分别为（22.31±6.39）分和（34.29±8.11）分,都显著低于治疗前的（65.20±7.19）分和（66.20±8.13）分（P〈0.05）,观察组治疗后的BASFI评分也显著低于对照组（P〈0.05）.两组治疗后的血清TNF-α 和CRP值都呈下降趋势,有统计学意义（P〈0.05）,且观察组血清TNF-α和CRP值的下降趋势与对照组相比更低（P〈0.05）.结论 补肾疏肝养血法联合沙利度胺治疗强直性脊柱炎能抑制TNF-α和CRP的表达,提高患者92的BASFI评分,缓解疼痛,从而提高治疗效果.

Objective To investigate the C-reactive protein（CRP）and tumor necrosis factor-α（TNF-α）effects of Bushenshuganyangxue soup combined thalidomide in the treatment of ankylosing spondylitis. Methods From January 2011 to February 2017,150 cases of patients with AS in Taihe hospital were selected and divided into observation group and control group with 75 cases in each group according to the order of ad-mission. The observation group were given Bushenshuganyangxue soup combined thalidomide treatment,the con-trol group were also given thalidomide treatment,two groups were both treated 3 months. Results The total ef-fective rate in the observation group （98. 7%）were higher than that of the control group（88%）（P 〈 0. 05）. The visual analogue scale（VAS）scores of night pain and spinal pain in the observation group and the control group after treatment were significantly lower than those before treatment（P 〈 0. 05）,and the observation group were also lower than that in the control group（P 〈 0. 05）. The bath as function index（BASFI）scores in the ob-servation group and the control group after treatment were（22. 31 ± 6. 39）points and （34. 29 ± 8. 11）points those were significantly lower than those before treatment （65. 20 ± 7. 19）points and （66. 20 ± 8. 13）points （P 〈 0. 05）,BASFI score after treatment in the observation group were also significantly lower than the control group （P 〈 0. 05）. The levels of TNF-α and CRP in the two groups were showed decreased trend （P 〈 0. 05）, and the decrease of TNF-α and CRP levels in the observed group were significantly lower than those in the con-trol group （P 〈 0. 05）. Conclusion The Bushenshuganyangxue soup combined thalidomide in the treatment of ankylosing spondylitis may effectively inhibit the expression of TNF-α and CRP,improve the BASFI score,re-lieve pain,and improve the therapeutic effect.