雷帕霉素靶蛋白对树突状细胞分化和功能的调节

mTOR-mediated regulation of dendritic cell differentiation and function

树突状细胞（dendritic cells,DCs）是重要的抗原提呈细胞,通过感受细胞内外环境,加工处理抗原以建立T细胞应答.雷帕霉素靶蛋白（mammalian target of rapamycin,mTOR）是一种进化保守的丝氨酸/苏氨酸激酶,参与诸多细胞过程.DC可通过mTOR复合物来调控自身的代谢、转录、翻译、抗原加工、细胞因子分泌以及对T细胞的活化.mTOR在调控DC分化和免疫功能中扮演重要的中心角色.

 Dendritic cells （DCs）are important antigen presenting cells that sense the extra-and intra-cellular environment to process antigens for the instruction of T cell responses. The mammalian target of rapamy-cin （mTOR）is an evolutionary conservative serine/ threonine kinase involved in many cellular processes. This review discusses how DCs use mTOR complexes （mTORC1 and mTOC 2）to adapt their cellular metabolism, transcriptional responses,and translation machinery to control DC development,antigen processing,cytokine pro-duction,and T cell activation. mTOR plays a central role that regulates DC differentiation and immune func-tions.