Ribociclib中间体的合成新方法

Novel Method Synthesis of Ribociclib Intermediate

研究了一种两步法合成瑞博西尼中间体2-氯-7-环戊基-N,N-二甲基-7H-吡咯并[2,3]嘧啶-6-甲酰胺的新工艺。该工艺试验条件温和,生产成本低,为其工业化生产提供了切实可行的实验方案。

We reported a simple method for the efficient synthesis of 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide in the synthetic approaches to ribociclib in two steps. This process has milder reactionconditions and low production cost, which provides a feasible and economical approaches for its industrial production.