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CPIS、PCT和D-二聚体对新生儿RDS并发呼吸机相关性肺炎预后评估的价值分析 被引量:3

THE VALUE OF CPIS, PCT AND D DIMER IN PROGNOSIS EVALUATION OF NEONATAL RDS COMPLICATED WITH VENTILATOR-ASSOCIATED PNEUMONIA
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摘要 目的:探讨临床肺部感染评分(CPIS)、D二聚体、降钙素原(PCT)对新生儿呼吸窘迫综合征(RDS)并发呼吸机相关性肺炎(VAP)预后评估的价值。方法:131例新生儿RDS并发VAP患儿根据病情转归分为生存组(75例)和死亡组(56例),记录所有患儿诊断VAP后第1天、第3天、第5天的CPIS评分、PCT和D二聚体水平。结果:诊断第3天、第5天,死亡组患儿的CPIS评分、D-二聚体、PCT均明显高于生存组,差异具有统计学意义(P<0.05)。随着诊断时间的延长,生存组患儿CPIS评分、D-二聚体、PCT逐渐降低(P<0.05),死亡组患儿CPIS评分、D-二聚体、PCT逐渐升高(P<0.05)。结论:监测CPIS评分、PCT、D-二聚体对新生儿RDS并发VAP的预后评估具有较好的临床价值。 bObjective: To investigate the value of clinical pulmonary infection score (CPIS), D dimer and procalcitonin (PCT) in prognosis evaluation of neonatal respiratory distress syndrome (RDS) complicated with ventilator associated pneumonia (VAP). Methods: 131 cases of neonatal RDS complicated with VAP children were divided into survival group (n=75) and death group (n=56) according to the disease prognosis. The CPIS, PCT and D dimer of all the children at the frst, third and ffth day of diagnosis were recorded. Results: At the third and ffth day of diagnosis, the CPIS, PCT and D dimer of children in death group were all obviously higher than survival group ( P〈0.05). With the prolongation of diagnosis time, the CPIS, PCT and D dimer of children in survival group decreased gradually ( P〈0.05), while the CPIS, PCT and D dimer of children in death group increased gradually ( P〈0.05). Conclusions: Monitoring CPIS, PCT and D dimers have good clinical value in predicting the prognosis of neonatal RDS complicated with VAP.
作者 张少雨 刘秀兰 孟林 桑艳锋 张冬梅 刘咏梅 ZHANG Shao-Yu;LIU Xiu-lan;MENG Lin(Pediatric Department of Chengde Central Hospital,Hebei Chengde 067000,China)
出处 《承德医学院学报》 2018年第5期380-383,共4页 Journal of Chengde Medical University
基金 承德市科技局项目(201601A012)
关键词 新生儿 呼吸窘迫综合征(RDS) 呼吸机相关性肺炎(VAP) 临床肺部感染评分(CPIS) 降钙素原(PCT) D-二聚体 Neonate Respiratory distress syndrome (RDS) Ventilator-associated pneumonia (VAP) Clinical pulmonary infection score (CPIS) Procalcitonin (PCT) D dimer
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