鼻用皮质类固醇对过敏性鼻炎(季节性)患者呼吸道NO浓度的影响

Nasal corticosteroids on the concentration of NO in respiratory tract of patients with(seasonal)allergic rhinitis

目的:探讨鼻用皮质类固醇治疗过敏性鼻炎(季节性)时,对患者呼吸道一氧化氮(NO)浓度的影响。方法:收治过敏性鼻炎患者50例作为试验组,选取同期健康志愿者50例为对照组。使用化学发光法检测患者的呼出NO浓度的情况,使用鼻用皮质类固醇治疗。结果:试验组治疗前后患者的口腔以及鼻腔呼出的NO浓度高于对照组(P<0.05)。试验组过敏性鼻炎患者治疗后鼻腔、口腔呼出的NO浓度均低于治疗前(P<0.05)。结论:鼻用皮质固醇类治疗过敏性鼻炎,能够降低鼻腔呼出的NO浓度,效果较好。

Objective：To investigate the effect of nasal corticosteroids on the concentration of NO in patients with（seasonal）allergic rhinitis.Methods：50 patients with allergic rhinitis were selected as the experimental group,and 50 healthy volunteers were selected as the control group.Chemiluminescence was used to detect the level of nitric oxide exhaled from the patient and treated with nasal corticosteroids.Results：The concentration of NO in the oral cavity and nasal cavity before and after the treatment in the experimental group was higher than that in the control group（P〈0.05）.After treatment,the concentration of NO in the nasal cavity and oral cavity of the experimental group was lower than that before the treatment（P〈0.05）.Conclusion：Nasal corticosteroids in treating allergic rhinitis can reduce the concentration of NO in nasal cavity exhalation,and the effect is better.