基于聚(N-乙烯基己内酰胺)的温度响应性聚合物在药物递送系统中的应用

Application of Temperature Responsive Polymer with Poly(N-vinylcaprolactam)in Drug Delivery System

温度响应性聚合物能通过感知温度而实现环境响应.该类聚合物能够对温度信号做出自反馈从而释放所包载的药物或中止释放,极大地增强了释药的持续性和专一性,同时提高药物的药效和安全性.聚(N-异丙基丙烯酰胺)(PNIPAM)是目前研究最多的温度响应性聚合物,而聚(N-乙烯基己内酰胺)(PNVCL)是一种仅次于PNIPAM的温度响应性聚合物,该温度响应性聚合物不仅有接近生理温度的相转变温度,而且其具有良好的生物相容性,生物可降解性,无毒性.因此,PNVCL在医疗器械,生物医学等方面具有广泛的应用价值,特别是作为药物输送载体而被重点关注.文章重点介绍了PNVCL与PNIPAM在生物特性方面的比较,对PNVCL最新发表的应用通过选定的实例进行了深入的研究,特别是在药物输送系统中的应用.结果表明,PNVCL将在纳米技术和环境应用中发挥关键作用.

Temperature responsive polymers can achieve environmental response by sensing tempera ture. Such polymers are capable of self feedback of temperature signals to release the entrapped drug or to suspend release, which can enhance the persistence and specificity of the drug release and improve the effi cacy and safety of the drug greatly. Poly（N isopropylacrylamide） （PNIPAM） is the most studied tempera ture responsive polymer, and poly（N vinylcaprolactam） （PNVCL） is second only to PNIPAM as a tern perature responsive polymer. The temperature responsive polymer not only has a phase transition tempera ture close to physiological temperature, but also has good biocompatibility, biodegradability, and no toxic ity. Therefore, PNVCL has a wide applications in medical devices, biomedicine, etc., especially as a drug delivery vehicle. This review highlights the comparison of PNVCL and PNIPAM in terms of biological properties. The latest published applications of PNVCL have been studied in depth through selected exam pies, particularly in drug delivery systems. The results show that PNVCL will play a key role in nanotech nology and environmental ap