摘要
骨质疏松症是老年人的常见病和多发病,骨组织来源细胞可分泌外泌体,包装和运载多种活性物质,如蛋白质、miRNAs、各种活性因子等,进行细胞间物质交换和信息交流,根据骨组织来源细胞外泌体和内容物的特点,利用其调节骨形成和骨吸收平衡的作用,甚至作为生物或基因治疗的载体,为老年骨质疏松症的防治提供全新的思路。
Osteoporosis is a common and frequently occurring disease in the elderly. Studies found that the bone derived cells can also secrete the exsomes packaging and delivering a variety of active substanc- es, such as protein, lniRNAs, various active factors, carrying out the exchange of material and information between cells. According to the characteristics and contents of bone-derived exosomes, they can be used to regulate bone forlnation and bone resorption balance, even as carrier of biological or gene therapy, this kind of research may provide a new idea for the prevention and treatment of osteoporosis in the elderly.
作者
吴石磊
刘勇
邵增务
田青
Wu Shilei;Liu Yong;Shao Zengwu;Tian Qing(Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,China)
出处
《中华老年骨科与康复电子杂志》
2018年第5期308-311,共4页
Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)
基金
国家自然科学基金青年科学基金(30800654)
关键词
骨质疏松症
外泌体
骨生成
骨吸收
Osteoporosis
Exosomes
Osteogenesis
Bone resorption
