丁苯酞联合阿替普酶治疗急性脑梗死的疗效及对神经功能、血液炎症因子水平的影响

Efficacy of butylphthalide combined with alteplase on acute cerebral infarction and its effects on neurological function and blood inflammatory factors

目的探讨丁苯酞联合阿替普酶治疗急性脑梗死(ACI)疗效及对神经功能、血液炎症因子水平的影响。方法选取我院100例急性脑死梗患者,随机分为观察组和对照组,各50例。对照组在常规药物的基础上给予阿替普酶治疗,观察组在对照组的基础上联合丁苯酞治疗。比较两组治疗总有效率,治疗前后脑神经功能和日常生活能力的恢复情况及血液炎症因子水平,不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05);治疗后,观察组患者脑神经功能和日常生活能力恢复情况优于对照组(P<0.05);观察组血液炎症因子IL-6、IL-10、TNF、CRP水平显著低于对照组(P<0.05)。结论 ACI患者应用丁苯酞联合阿替普酶治疗可有效恢复患者的脑神经功能,降低血液炎症因子水平,临床治疗效果较好。

Objective To explore the efficacy of butylphthalide combined with alteplase on acute cerebral infarction（ACI） and its effects on neurological function and blood inflammatory factors. Methods A total of 100 patients with ACI inour hospital were selected and randomly divided into observation group and control group, with 50 cases in each group. Thecontrol group was given alteplase on the basis of conventional drugs, and the observation group was treated withbutylphthalide on the basis of the control group. The total effective rate of treatment, and the recovery of brain neurologicalfunction and daily living ability, and blood inflammatory factors before and after treatment and adverse reactions werecompared between the two groups. Results The total effective rate of treatment in the observation group was significantlyhigher than that in the control group（P〈0.05）. After treatment, the recovery of neurological function and daily living abilityin the observation group were better than those of the control group（P〈0.05）. The levels of blood inflammatory factor IL-6,IL -10, TNF, and CRP in the observation group were significantly lower than those in the control group （P〈0.05）. Conclusion Butylphthalide combined with alteplase for ACI patients can effectively restore the brain neurological function,and reduce blood inflammatory factors levels, which has good clinical treatment effects.