氨氯地平联合厄贝沙坦片治疗2型糖尿病患者脑出血急性期的疗效及安全性

Efficacy and safety of amlodipine combined with irbesartan tablet in the treatment of acute stage of cerebral hemorrhage in patients with type 2 diabetes mellitus

目的探讨氨氯地平联合厄贝沙坦片治疗2型糖尿病患者脑出血急性期的疗效及安全性。方法选择收治的2型糖尿病合并脑出血急性期患者84例,采用随机数字表法分为对照组和观察组,各42例。对照组采用常规治疗,观察组在对照组基础上加用氨氯地平与厄贝沙坦片治疗。观察两组治疗前、后神经功能缺损情况、血糖波动情况及不良反应发生率。结果治疗后,两组患者NIHSS及MESSS评分、MODD及MAGE水平均显著降低,且观察组低于对照组(P<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 2型糖尿病患者脑出血急性期联合应用氨氯地平和厄贝沙坦片疗效显著,可明显改善患者的神经功能,减少血糖波动,且安全性高,值得推广。

Objective To investigate the efficacy and safety of amlodipine combined with irbesartan in the treatment ofacute stage of cerebral hemorrhage in patients with type 2 diabetes mellitus. Methods A total of 84 patients with type2diabetes mellitus complicated with acute stage of cerebral hemorrhage treated in our hospital were selected and dividedinto control group and observation group according to the randomized digital table method, with 42 cases in each group.The control group was given routine treatment, and the observation group added amlodipine and irbesartan tablet on thebasis of the control group. The neurological deficits, blood glucose fluctuations before and after treatment and adversereactions were observed in the two groups. Results After treatment, the NIHSS and MESSS scores, levels of MODD andMAGE in the two groups significantly reduced, and those of the observation group were significant lower than the controlgroup（P〈0.05）. The total incidences of adverse reactions between the two groups were no statistically significant（P〉0.05）.Conclusion Amlodipine combined with irbesartan tablet in the treatment of acute stage of cerebral hemorrhage in patientswith type 2 diabetes mellitus is significantly effective, which can obviously improve the neurological function, reduce bloodsugar fluctuations and has high safety. It is worthy of clinical application.