ESW联合塞来昔布治疗早中期膝关节骨性关节炎的疗效及安全性

Efficacy and safety of ESW combined with celecoxib in the treatment of knee osteoarthritis in early and middle stages

目的研究体外冲击波(ESW)联合塞来昔布治疗早中期膝关节骨性关节炎(KOA)的疗效及安全性。方法选取我院收治的104例早中期KOA患者为研究对象,采用随机数表法将患者分为对照组和观察组,各52例。对照组采用ESW治疗,观察组在对照组的基础上加服塞来昔布。比较两组患者的临床疗效。结果疗程结束时、随访6个月时,两组患者VAS、Lysholm、WOMAC评分和炎性因子水平均较治疗前明显改善,且观察组优于对照组(P<0.05)。随访6个月,观察组愈显率明显高于对照组(P<0.05),且无明显不良反应。结论 ESW联合塞来昔布治疗早中期KOA患者的临床效果显著。

Objective To study the efficacy and safety of extracorporeal shock wave （ESW） combined with celecoxib in thetreatment of knee osteoarthritis （KOA） in the early and middle stages. Methods A total of 104 cases of patients with KOA inour hospital were selected as the objects and divided into control group and observation group by random digital method, with52 cases in each group. The control group was treated with ESW, and the observation group added celecoxib on this basis.The clinical efficacy of the two groups were compared. Results At the end of treatment and6 months of follow-up, the scoresof Lysholm, VAS and WOMAC, the levels of inflammatory factors significantly improved, and those of the observation groupwere better than the control group（P〈0.05）. Follow-up for 6 months, the markedly effective rate in the observation group wassignificantly higher than that in the control group （P〈0.05）, and there was no obvious adverse reactions. Conclusion ESWcombined with celecoxib in the treatment of KOA patients in the early and middle stages has significant clinical effect.