肠杆菌对抗生素的耐药性研究进展

Advances in research on resistance of enterobacterium to antibiotics

肠杆菌是医学、兽医临床感染中常见的致病菌,大肠杆菌对多种抗生素耐药主要与菌体中存在的外排泵有关。研究肠杆菌的多重耐药机制将为临床抗生素的合理使用提供科学指导。在肠杆菌科中发现抗生素抗性基因存在基因水平转移,表明肠杆菌适应抗生素药物的分子进化机制。此外,Mar操纵系统是肠杆菌科外排泵表达的重要调节系统,可以调控肠杆菌科抗性基因表达最终影响肠杆菌对抗生素的多重耐药性。肠杆菌耐药菌株既有致病性又有抗性。在大肠杆菌多重耐药较为严重的情况下,其MarR调控子如何控制对AcrAB外排泵的表现方式,继而引发大肠杆菌多重耐药性的研究还有很长的路要走。

Enterobacterium is a common pathogenic bacteria in medical and veterinary clinical infection. The E. coliresistance to multiple antibiotics is mainly related to the presence of efflux pumps in the bacteria. The study of multipledrug resistance mechanisms of Enterobacterium will provide scientific guidance for the rational use of clinical antibiotic.The phenomenon that gene horizontal transfer of antibiotic resistance gene is found in enterobacteriaceae, which indicatesthe molecular evolution mechanism of the adaptation of Enterobacterium to antibiotic drugs. Mar control system is animportant regulatory system for the expression of enterobacteriaceae efflux pump, which can regulate the expression ofresistance genes of enterobacteriaceae and ultimately affect the multidrug resistance of Enterobacterium to antibiotics.Enterobacteriaceae resistant strains are both pathogenic and resistant. In the case of multiple drug resistance in E. coli,how the MarR regulator regulates the expression level of AcrAB efflux pump, which in turn causes E. coli multi-drugresistance remains to be further studied.