奥曲肽与泮托拉唑联合治疗上消化道出血的临床观察

Clinical observation of octreotide combined with pantoprazole in the treatment of upper gastrointestinal hemorrhage

目的研究奥曲肽和泮托拉唑治疗上消化道出血的临床疗效。方法选择240例呈现上消化道出血症状的患者,以数字随机表方法将其分为两个组别,分别为观察组和对照组。观察组的患者125例,主要使用奥曲肽和泮托拉唑联合进行治疗,对照组的患者115例,该组单纯给予泮托拉唑进行治疗,对两组的治疗疗效、围手术期指标、SF-36评分及后续的1个月随访过程中不良反应状况进行对比观察,总结性评判奥曲肽和泮托拉唑针对上消化道出血治疗的具体疗效状况。结果经治疗,发现观察组治疗有效率显著高于对照组(P<0.05),观察组出血时间相比对照组较短,且输血量相比对照组明显偏少;但是血红蛋白水平、胃液p H值比对照组高,差异具有统计学意义(P<0.05)。在1个月的治疗时间过后,观察组生理功能、生理职能、躯体疼痛方面的评分显著高于对照组(P<0.05),其他各项评分差异无统计学意义。结论奥曲肽和泮托拉唑联合治疗上消化道出血症状的疗效突出,可以快速止血,降低血液流失与输血量,优化患者生活品质,用药更加安全,适合在临床进行推广。

Objective To study the clinical efficacy of octreotide and pantoprazole in the treatment of upper gastrointestinal bleeding. Methods Atotal of 240 patients with upper gastrointestinal bleeding symptoms were selected and divided into two groups by digital random table method, whichwere observation group and control group. 125 patients in the observation group were treated with octreotide and pantoprazole. 115 patients in thecontrol group were treated with pantoprazole alone. The therapeutic efficacy, perioperative index, and SF of the two groups were compared. The SF -36 score and subsequent follow-up of 1-month follow-up were compared, and the specific efficacy of octreotide and pantoprazole for upper gastrointestinalbleeding was evaluated. Results After treatment, the effective rate of the observation group was significantly higher than that of the controlgroup （P〈0.05）. The bleeding time of the observation group was shorter than that of the control group, and the blood transfusion volume was significantlyless than that of the control group; however, the hemoglobin level and the pH of the gastric juice were lower. Compared with the controlgroup, the difference was statistically significant （P〈0.05）. After 1 month of treatment, the scores of physiological function, physiological functionand physical pain of the observation group were significantly higher than those of the control group （P〈0.05）. There was no significant difference inother scores. Conclusion The combination of octreotide and pantoprazole in the treatment of upper gastrointestinal hemorrhage has outstanding curativeeffect. It can quickly stop bleeding, reduce blood loss and blood transfusion, optimize the quality of life of patients, and make medication safer.It is suitable for clinical promotion.