加味小柴胡汤联合拉米夫定治疗慢性乙型肝炎80例

Treating 80 Cases of Patients with Chronic Hepatitis B by Using Modified Xiaochaihu Decoction Combined with Lamivudine

目的:观察加味小柴胡汤联合拉米夫定治疗(HCB)的临床疗效。方法:收集HCB病例80例,随机分为实验组和对照组,每组各40例。实验组给予加味小柴胡汤及拉米夫定;对照组仅给予拉米夫定。6个月后,比较两组肝功能(血清ALT、AST、TBIL、ALB、A/G含量)、HBe Ag及HBV-DNA转阴率、肝纤维化情况(血清IV-C、HA、LN及PC-Ⅲ含量)有无明显差异。结果:实验组患者肝功能、肝纤维化程度较对照组明显改善,HBV-DNA转阴率明显优于对照组(P<0.05)。结论:加味小柴胡汤联合拉米夫定治疗HCB的效果显著优于单纯使用拉米夫定。

Objective： To observe whether the effect of treating HCB with Modified Xiaochaihu Decoction combined with Lamivudine is better than that of using Lamivudine only. Method： 80 cases of patients with HCB were collected,and randomly divided into an experimental group and a control group. The patients in the experimental group were treated with Modified Xiaochaihu Decoction combined with Lamivudine,while the patients in the control group were treated with Lamivudine only. Then the liver function（ the content of ALT,AST,TBIL,ALB,A/G）,the negative conversion ratio of HBe Ag and HBV-DNA,and Liver fibrosis（ the content of IV-C,HA,LN and PC-Ⅲ） were compared after 6 months＇ treatment to see whether there were obvious difference. Result： The liver function,liver fibrosis and HBV-DNA negative conversion ratio of the experimental group were obviously improved than those of the control group. Conclusion： The effect of treating HCB with Modified Xiaochaihu Decoction combined with Lamivudine is significantly better than that of using Lamivudine only.