204例中华跌打丸不良反应分析

Analysis of Adverse Drug Reactions of Zhonghuadieda Pills in 204 Cases

目的:分析中华跌打丸不良反应(ADR)的发生特点、相关因素及临床转归,为临床合理用药提供依据。方法:利用全国药品不良反应监测网络管理平台,对2010-2014年涉及中华跌打丸不良反应的204例报告中患者年龄与性别、累及器官和(或)系统及转归性进行回顾性分析。结果:204例ADR报告中,男性患者147例(占72.06%),女性患者57例(占27.94%),ADR主要累及胃肠系统损害,最常见的不良反应为恶心、腹痛、皮疹。结论:医院应全面加强对药品ADR的监测,减少ADR的发生,保证患者安全用药。

Objectives： The purpose of the study was to analyze the occurrence rule, influencing factors and clinical outcome of Zhonghuadieda Pills adverse drug reactions （ADR） and to provide a reference for the clinical reasonable use of the drug. Methods： The study includes 204 cases of Zhonghuadieda Pills ADR reported by National ADR Monitoring System from 2010 to 2014. The age, gender, involved organs and or systems, clinical outcome of the cases were retrospectively analyzed. Results： In the 204 ADR reports, 147 （72.06%） male patients and 57 （27.94%） female patients, ADR mainly involved gastrointestinal system damage, the most common of which were nausea, abdominal pain, and rash. Conclusion： ADR monitoring should be overall reinforced so that to reduce its frequency and to ensure patients with safe medication.