老年细菌性肺炎患者血清脂联素及瘦素水平与肺炎严重程度的相关性研究

Changes in serum adiponectin and leptin concentration in senile patients with bacterial pneumonia and the association with severity of pneumonia

目的探讨老年细菌性肺炎患者血清脂联素、瘦素水平与炎症标记物降钙素原（PCT）、C反应蛋白（CRP）及肺炎严重指数（PSI）的相关性。方法选择2016年6月至2017年6月的煤炭总医院收治重症肺炎（sP）患者32例，其中男20例，女12例，同期住院的30例老年普通肺炎（NSP）患者作为对照组，其中男18例，女12例，并另取30例老年无肺炎体检者作为正常对照组（HC），检测血清脂联素、瘦素、PCT及CRP水平，并对患者进行PSI评分。结果三组患者基线资料差异无统计学意义。NSP组和SP组的脂联素水平低于对照组，SP组水平最低，差异均有统计学意义；NSP组和SP组的瘦素水平高于对照组，SP组水平最高，差异均有统计学意义；脂联素水平与PCT、CRP及PSI评分呈负相关关系（r=-0．376、-0．397、-0．410，P〈0．05或〈0．01），瘦素水平与PCT、CRP及PSI评分呈正相关关系（r=0．677、0．353、0．256，P〈0．05或〈0．01）。结论血清脂联素和瘦素可以作为一种反映感染严重程度的指标，对老年细菌性肺炎严重程度有一定的评估作用。

Objective To explore the level of plasma adiponeetin, leptin level in elderly patients with bacterial pneumonia and its correlation with procalcitonin （PCT）, C-reactive protein （CRP） and pneumonia severity index （PSI）. Methods 32 patients with severe pneumonia （SP group）, 30 patients with non-severe pneumonia （NSP group）, and 30 patients without pneumonia （healthy control） were included into this study. The levels of adiponeetin, leptin, PCT and CRP were detected, and PSI was performed. Results Compared with the healthy control group, the levels of adiponectin in NSP and SP group decreased significantly, the lowest was in SP group;The levels of leptin in NSP and SP group were increased, the highest was in SP group. The levels of adiponectin had positive correlation with PCT, CRP and PSI （r=-0.376,-0.397,-0.410, P 〈0.05或〈0.01）,but the levels of leptin had negative correlation with PCT,CRPandPSI （r =0.677,0.353,0.256, P 〈0.05 or〈0.01）.Conclusions As an index, adiponectin and leptin can reflect the severity of the infection. The level of adiponectin and leptin can evaluate the severity of elderly patients with bacterial pneumonia.