PVS患者PICC导管不同封管液封管的效果比较

Comparative study on efficacy of two different solutions for sealing of peripherally inserted central catheter in persistent vegetative state patients

目的探讨针对持续性植物状态(PVS)患者经外周穿刺置入中心静脉导管(PICC)使用不同封管液的封管效果。方法 60例PICC置管PVS患者随机观察组和对照组,各30例。对照组采用SAS法(S:生理盐水20 mL; A:给药; S:生理盐水20 mL),观察组选择SASH法(S:生理盐水20 mL; A:给药; S:生理盐水20mL; H:125 U/mL肝素盐水5 mL)。比较2组堵管发生率和凝血指标变化。结果观察组堵管发生率3. 33%(1/30),低于对照组的40. 00%(12/30),差异有统计学意义(P <0. 05)。2组凝血指标变化差异无统计学意义(P> 0. 05)。结论肝素液封管可有效预防堵管发生,且对患者凝血状态无明显影响。

Objective To compare the efficacy of two different solutions for sealing of pe- ripherally inserted central catheter （PICC） in persistent vegetative state （PVS）patients. Methods Totally 60 PVS patients with PICC were assigned to the observation group and the control group, with 30 cases in each group. The SAS （S： 20 mL saline, A： intravenous administration; S： 20 mL saline） was used for sealing of PICC in the control group, and the SASH（ S ： 20 mL sa- line ; A ： intravenous administration; S ：20 mL saline; H ： 5 mL of 125 U/mL heparin-saline） was used for sealing of PICC I the observation group. The rate of catheter blockage and changes of blood coagulation indicators were observed and compared between two groups. Results The rate of catheter blockage was 3.33 % （1/30） in the observation group, which was lower than 40.00% （12/30） in the control group （P 〈 0.05）. There was no significant difference in change of relat- ed blood coagulation indicators between two groups （ P 〉 0.05 ）. Conclusion The use of hepa- rin-saline as a sealing solution dose not affect the coagulation of PVS patients with PICC. It can effectively prevent the catheter blockage of PICC.