阿卡波糖与二甲双胍分别联合格列齐特治疗T2DM患者疗效对比

Efficacy comparison of Acarbose or Metformin separately combined with Gliclazide in the treatment of patients with Type 2 diabetes mellitus

目的研究阿卡波糖与二甲双胍分别联合格列齐特治疗2型糖尿病(T2DM)患者的疗效对比。方法 150例T2DM患者,按随机数字表法分为对照组和观察组,每组75例。两组患者均进行常规饮食控制、运动治疗,均服用格列齐特。在此基础上,对照组服用二甲双胍治疗,观察组服用阿卡波糖治疗。观察比较两组患者治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹血清胰岛素(FINS)水平。结果两组患者治疗后FPG、2 h PG水平均低于治疗前,差异具有统计学意义(P<0.05);治疗后观察组FPG(6.24±1.05)mmol/L、2 h PG(8.77±1.64)mmol/L显著低于对照组的(7.05±1.19)、(10.35±1.92)mmol/L,差异有统计学意义(P<0.05)。两组患者治疗后的Hb A1c水平低于治疗前,FINS水平高于治疗前,差异具有统计学意义(P<0.05);观察组患者治疗后的Hb A1c水平低于对照组,FINS水平高于对照组,差异具有统计学意义(P<0.05)。结论阿卡波糖联合格列齐特治疗T2DM疗效更好。

Objective To research the comparison of curative effect of Acarbose or Metformin separately combined with Gliclazide in the treatment of patients with type 2 diabetes mellitus（T2 DM）. Methods A total of 150 T2 DM patients were divided into control group and observation group according to the random number table method, 75 cases in each group. The two groups were given routine diet control and exercise therapy, and were treated with Gliclazide. On this basis, the control group was given Metformin for treatment, the observation group was given Acarbose for treatment. The levels of fasting plasma glucose（FPG）, postprandial 2 h plasma glucose（2 h PG）, glycosylated hemoglobin（Hb A1 c）, fasting serum insulin（FINS） between the two groups before and after treatment were observed and compared. Results After treatment, the levels of FPG and 2 h PG in the two groups were significantly lower than those before treatment, the differences were statistically significant（P〈0.05）. After treatment, the levels of FPG and 2 h PG in the observation group were（6.24±1.05） mmol/L and（8.77±1.64） mmol/L respectively, which were significantly lower than（7.05±1.19） mmol/L and（10.35±1.92） mmol/L in the control group, the differences were statistically significant（P〈0.05）. After treatment, the level of HBA1 c in the two groups were significantly lower than those before treatment, and the level of FINS in the two groups were significantly higher than those before treatment, the differences were statistically significant（P〈0.05）. The level of HBA1 c in the observation group after treatment was significantly lower than that in the control group, and the level of FINS in the observation group was significantly higher than that in the control group, the differences were statistically significant（P〈0.05）. Conclusion The curative effect of Acarbose combined with Gliclazide in the treatment of patients with T2 DM is better.