低频重复经颅磁刺激结合草酸艾司西酞普兰治疗轻中度抑郁症睡眠障碍的效果

Effect of low frequency repetitive transcranial magnetic stimulation combined with Escitalopram oxalate on sleep disorders in mild to moderate depression

目的探讨低频(1 Hz)重复经颅磁刺激结合草酸艾司西酞普兰治疗轻中度抑郁症睡眠障碍的效果。方法 100例轻中度抑郁症睡眠障碍患者,随机分为观察组和对照组,每组50例。对照组患者应用草酸艾司西酞普兰进行治疗,观察组患者在对照组基础上增加低频重复经颅磁刺激进行联合治疗。观察对比两组患者治疗前后的匹兹堡睡眠质量指数(PSQI)评分和汉密尔顿抑郁量表(HAMD-17)总分。结果治疗后,两组患者的PSQI总分和各因子评分均低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。对照组和观察组患者治疗前的HAMD-17总分分别为(22.63±1.92)、(23.05±1.61)分,治疗后分别为(17.27±2.36)、(14.56±1.66)分;治疗后,两组患者的HAMD-17总分均低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论与单纯应用草酸艾司西酞普兰相比,低频重复经颅磁刺激结合草酸艾司西酞普兰治疗轻中度抑郁症睡眠障碍的效果更为显著。

Objective To investigate low frequency（1 Hz） repetitive transcranial magnetic stimulation combined with Escitalopram oxalate on sleep disorders in mild to moderate depression. Methods A total of 100 mild to moderate depression with sleep disorders were randomly divided into observation group and control group, 50 cases in each group. Patients in the control group were treated with Escitalopram oxalate, and patients in the observation group were treated with low frequency repetitive transcranial magnetic stimulation on the basis of the control group. The Pittsburgh sleep quality index（PSQI） score and Hamilton depression scale（HAMD-17） total score before and after treatment between the two groups were observed and compared. Results After treatment, the PSQI total score and the scores of each factors of the two groups were significantly lower than those before treatment, and above indexes of the observation group were significantly lower than those in the control group, the differences were statistically significant（P〈0.05）. The HAMD-17 total score of the control group and the observation group before treatment were（22.63±1.92） scores and（23.05±1.61） scores respectively, the HAMD-17 total score of the control group and the observation group after treatment were（17.27±2.36） scores and（14.56±1.66） scores respectively. After treatment, the total score of HAMD-17 in the two groups were significantly lower than those before treatment, and that in the observation group was significantly lower than that of the control group, the differences were statistically significant（P〈0.05）. Conclusion Compared with Escitalopram oxalate alone, low frequency repetitive transcranial magnetic stimulation combined with Escitalopram oxalate in the treatment of mild to moderate depression with sleep disorders is more effective.