摘要
HBV pgRNA是HBV cccDNA的直接转录产物,能够通过反映HBV cccDNA的转录活动状态进而反映慢性乙型肝炎病情进展,指导临床治疗和判断预后。与其他常用HBV感染血清标志物相比,HBV pgRNA在反映HBV复制活动和抗病毒治疗效果等方面更灵敏,对于抗病毒治疗阶段终点有预测价值。通过综合HBV pgRNA与HBcrAg、HBV cccDNA的相关性来阐述HBV pgRNA在反映慢性乙型肝炎治疗过程中病情变化的可能意义。
Hepatitis B virus（ HBV） pregenomic RNA（ pgRNA） is the direct transcription product of HBV covalently closed circular DNA（ cccDNA） and can reflect the transcriptional activity of HBV cccDNA and the progression of chronic hepatitis B,which provides guidance for clinical treatment and prognostic prediction. Compared with other common serological markers for HBV infection,HBV pgRNA is more sensitive in reflecting HBV replication and the effect of antiviral therapy has a certain predictive value for endpoints in the stages of antiviral therapy. This article elaborates on the significance of HBV pgRNA in reflecting the changes in disease conditions with reference to the correlation of HBV pgRNA with HBcrAg and HBV cccDNA.
作者
谭宁
罗皓
徐小元
TAN Ning, LUO Hao, XU Xiaoyuan(Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第10期2221-2223,共3页
Journal of Clinical Hepatology
基金
传染病国家科技重大专项(2017ZX10302201-004-009)
北京市科技计划项目(D161100002716003
D161100002716002
D171100003117005)
关键词
肝炎
乙型
慢性
HBV
pgRNA
HBcrAg
综述
hepatitis B
chronic
HBV pregenomic RNA
hepatitis B core - related antigen
review
