非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素

Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis

目前,非酒精性脂肪性肝病(NAFLD)已经成为全球慢性肝病的主要病因,是隐源性肝硬化的常见致病因素。临床上,NAFLD患者多见于肥胖群体,但非肥胖人群中NAFLD亦不罕见,尤其是亚洲人群。非肥胖型NAFLD与肥胖型NAFLD代谢谱相当,但最近多项研究显示与肥胖型NAFLD相比,非肥胖型肝纤维化、肝硬化有其独特的特点。回顾了近年来非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素,以期更好地了解该病的预防、诊断和治疗。

At present,non-alcoholic fatty liver disease（ NAFLD） has become the major cause of chronic liver disease in the world and is considered a common pathogenic factor of cryptogenic cirrhosis. In clinical practice,NAFLD is commonly seen in obese patients; however,it is not rare among non-obese individuals,especially in the Asian population. Non-obese NAFLD patients have similar metabolic profiles to obese NAFLD patients,but many studies have revealed that compared with obese NAFLD,non-obese liver fibrosis and liver cirrhosis have unique features. This article reviews the research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis in recent years,in order to gain a better understanding of the prevention,diagnosis,and treatment of this disease.