非酒精性脂肪性肝病的治疗进展

Research advances in the treatment of nonalcoholic fatty liver disease

非酒精性脂肪性肝病已成为我国健康人群肝酶异常的首要原因。由于其发病机制复杂,目前尚未达成治疗共识。但近年来,越来越多的研究逐渐提出了更多的发病机制及对应的治疗推荐。介绍和总结了其治疗方式,涉及生活方式干预、药物治疗、根除幽门螺杆菌、手术治疗、调节肠道微生态、基因治疗等方面的研究进展。

Nonalcoholic fatty liver disease（ NAFLD） has become the leading cause of abnormal liver enzymes in healthy individuals in China. Due to the complex pathogenesis of NAFLD,no consensus has been reached on the treatment of this disease. However,in recent years,more and more studies have put forward more pathogeneses and corresponding treatment recommendations. This article introduces and summarizes the research advances in the treatment of NAFLD,including lifestyle intervention,drug treatment,eradication of Helicobacter pylori,surgical treatment,regulation of intestinal microecology,and gene therapy.