富含脯氨酸蛋白11在胆囊癌组织中的表达及意义

Expression and significance of PRR11 in gallbladder carcinoma

目的探讨富含脯氨酸蛋白11(PRR11)在胆囊癌组织中的表达及意义。方法用免疫组织化学染色SP法测定58例人胆囊癌、癌旁组织和49例慢性胆囊炎组织中PRR11蛋白的表达情况,统计分析其与胆囊癌组织学类型、胆囊癌Nevein分期、淋巴结转移、组织分化等临床病理参数的关系。结果 PRR11蛋白在胆囊癌中的阳性表达率为55.2%(32/58),远高于其在癌旁组织25.9%(15/58)和慢性胆囊炎4.1%(2/49)中的阳性表达率(均P <0.01)。PRR11的表达在不同Nevein分期、组织分化程度和有无淋巴结转移分组中比较,差异有统计学意义(均P <0.01),而不同年龄、性别及组织学分型分组比较,差异无统计学意义。结论 PRR11蛋白在胆囊癌组织中高表达,而在癌旁组织和慢性胆囊炎组织中微弱表达或不表达,提示其可能参与胆囊癌的发生、侵袭及转移的过程。

Objective To investigate the expression and significance of proline-rich protein 11 （PRR11） in gallbladder carcinoma. Methods The expressions of PRR11 were detected by immunohistochemistly SP method in gallbladder carcinoma and paracancerous tissues of 58 patients and samples of 49 cases of chronic cholecystitis. The relationship between staining resuhs and clinicopathological parameters （types of tissues, Nevein stage of gallbladder carcinoma, lymph node metastasis and tissue differentiation） of gallbladder cancer was analyzed. Results The positive expression rate of PRR11 protein in gallbladder carcinoma was 55.2% （32/58）, which was much higher than that in the adjacent tissue （25.9%, 15/58） and chronic cholecystitis （4.1%, 2/49, P 〈 0.01）. There were significant differences in expressions of PRR11 between different stages of Nevein, different degrees of tissue differentiation and with or without lymph node metastasis （P 〈 0.05）, but there was no significant difference in expression of PRR11 between age, gender and tissue classification. Conclusion PRR11 protein is highly expressed in gallbladder carcinoma tissues, but weakly expressed or not expressed in paracancerous tissues and chronic cholecystitis tissues, suggesting that PRR11 may be involved in the occun＇ence, invasion and metastasis of gallbladder carcinoma.