摘要
心型脂肪酸结合蛋白(H-FABP)是小分子蛋白质,主要在心脏中表达,在长链脂肪酸进入线粒体进行β氧化时起着关键的作用。目前临床上H-FABP用于持续的心肌损伤及急性心肌梗死(AMI)早期诊断标志物,越来越多的研究表明,H-FABP与急性冠脉综合征、心力衰竭、心律失常等疾病的诊断和预后有密切关系。
Heart-type fatty acid-binding prolein （H-FABP） is a small molecular protein, which is mainly expressed in heart and plays a key role in mitochondrial β oxidation through partitioning of long-chain fatty acids toward the mitochondria. Nowadays, H-FABP is clinically used for the early diagnosis of persistent myocardial injury and acute myocardial infarction （AMI）. More and more studies have showed that H-FABP is closely related to the diagnosis and prognosis of acute coronary syndrome, heart failure and arrhythmia.
作者
王翠华
刘衍恭
郑明奇
WANG Cui-hua;LIU Yan-gong;ZHENG Ming-qi(Heart Center,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Department ofPathophysiology,Oita University School of Medicine,Japan)
出处
《天津医药》
CAS
北大核心
2018年第10期1135-1139,共5页
Tianjin Medical Journal
基金
河北省科技计划项目(16277707D)
河北省自然科学基金面上项目(H2015206386)
河北省医学科学研究重点课题计划(20150191)
关键词
心血管疾病
心律失常
心性
心力衰竭
诊断
预后
心型脂肪酸结合蛋白
急性心肌梗死
cardiovascular diseases
arrhythmias, cardiac
heart failure
diagnosis
prognosis
heart-type fatty acid-binding protein
acute myocardial infarction
