凝血与炎症因子指标在中重度卵巢内异症患者中的作用

The Role of Coagulation and Inflammatory Factors in Patients With Moderate to Severe Ovarian Endomesia

目的探究凝血与炎症因子指标在中重度卵巢内异症患者中的检测价值。方法回顾性分析2015年6月—2018年6月我院收治的80例中重度卵巢内异症和同期80例良性卵巢囊肿非内异症患者的临床资料。比较内异症与非内异症患者、不同期别内异症患者的凝血与炎症因子指标,分析凝血与炎症因子指标在中重度卵巢内异症患者中的检测价值。结果内异症患者血清D-D、NLR、纤维蛋白原FIB和PLR均高于非内异症患者,PT和TT均低于非内异症患者,差异具有统计学意义(P <0.05)。Ⅳ期内异症患者血清FIB、PLR、PLT均高于Ⅲ期内异症患者,PT低于Ⅲ期内异症患者,差异具有统计学意义(P <0.05)。绘制ROC曲线发现,PT、TT、PLR和NLR的AUC分别为0.569、0.594、0.586、0.579,均低于0.6,具有较低的诊断价值。FIB的AUC为0.657,诊断界值为3.1 g/L,特异度为72.7%,灵敏度为53.2%。结论凝血与炎症因子异常与中重度卵巢内异症有一定相关性,临床中可通过检测凝血与炎症因子对患者进行临床诊治。

Objective To investigate the detection value of coagulation and inflammatory factors in patients with moderate to severe ovarian endometriosis. Methods The clinical data of 80 patients with moderate to severe ovarian endometriosis and 80 patients with benign ovarian cyst non-endometriosis admitted to our hospital from June 2015 to June 2018 were retrospectively analyzed. The coagulation and infammatory factors in patients with endometriosis and non-endometriosis were compared, and in different stages of endometriosis, and the detection value of coagulation and inflammatory factors in patients with moderate to severe ovarian endometriosis was analyzed. Results Serum DD, NLR, and fbrinogen （FIB and PLR were higher in patients with endometriosis than those with non-endometriosis, PT and TT were lower than those in non-endometriosis patients, the difference was statistically significant （P 〈 0.05）. The serum FIB, PLR and PLT of patients with heterosis of patients with stage IV were higher than those of patients with stage III disease. The diference of PT was lower than that of patients with stage III （P 〈 0.05）. The ROC curve was found to be PT and TT. The AUC of PLR and NLR were 0.569, 0.594, 0.586, and 0.579, respectively, both lower than 0.6, which had lower diagnostic value. The AUC of FIB was 0.657, the diagnostic threshold was 3.1 g/L, and specifcity was 72.7%, the sensitivity was 53.2%. Conclusion There is a certain correlation between abnormal blood coagulation and inflammatory factors and moderate to severe ovarian endometriosis. Clinically, patients can be diagnosed and treated by detecting blood coagulation and infammatory factors.