左氧氟沙星治疗社区获得性肺炎临床评价及对炎症因子的影响

Clinical evaluation of Levofloxacin in the treatment of community acquired pneumonia and its effect on serum Creactive protein

目的探讨左氧氟沙星在社区获得性肺炎治疗中的应用效果及对患者炎症因子的影响。方法选取2016年1月—2017年12月于我院就诊的社区获得性肺炎患者80例,随机等分为观察组(n=40)与对照组(n=40),对照组予以阿奇霉素治疗,观察组在此基础上联合左氧氟沙星治疗,对比2组治疗效果及炎症因子水平。结果观察组患者的治疗总有效率显著高于对照组(P<0.05)。观察组患者的发热、咳痰、肺部啰音、喘鸣音消失时间显著短于对照组(P<0.05);观察组患者治疗后的TNF-α、IL-5、MMP-2、PCT水平显著低于对照组(P<0.05)。结论左氧氟沙星可改善社区获得性肺炎患者的临床症状及体征,减轻患者的炎症状态,疗效良好,值得临床借鉴推广。

Objective To investigate the effect of levofloxacin in the treatment of community acquired pneumonia and its influence on inflammatory factors. Methods 80 patients with community-acquired pneumonia in our hospital from Januany 2016 to December 2017 were divided into observation group and eonlrol group.The control group was given azithromyein.The observation group was treated with azithromyein combined with levofloxaein, and the therapeutic effeets and levels of inflammatory factors were compared between the two groups. Results The lotal effective rate of the observation group was significantly higher than that of the control group （P〈0.05）.The disappearance time of fever, cough, lung snoring and wheezing in the observation group was significantly shorter than that in the control group （P〈0.05）.The levels of TNF-a, IL-5, MMP-2 and PCT in the observation group were significantly lower than those in the control group （P〈0.05）.Conclusion Levofloxacin is effective in the treatment of community-acquired pneumonia, and reducing the inflammatory state of the patients, the clinical curative effect is good, so it is worth clinical reierence and promotion