阿奇霉素联合阿司匹林治疗慢性阻塞性肺疾病急性加重期患者的临床效果

Clinical analysis of combined use of azithromycin and aspirin in the treatment of chronic obstructive pulmonary disease during acute exacerbation

目的:探讨联合运用阿奇霉素与阿司匹林治疗慢性阻塞性肺疾病急性加重期患者的疗效。方法:将105例具有完整临床信息的慢性阻塞性肺疾病急性加重期患者作为本文研究对象,按照患者入院时间的先后顺序分为对照组(n=52)与观察组(n=53),观察组给予常规抗炎解痉化痰联合阿奇霉素与阿司匹林治疗,对照组采用常规抗炎化痰解痉治疗,观察两组治疗效果。结果:观察组的整体有效率为94. 3%,高于对照组的80. 8%(P <0. 05);观察者的用力肺活量(Forced vital capacity,FVC)、1秒用力呼吸容积(1 second forced breathing volume,FEV1)以及用力呼吸量/用力肺活量(FEV1/FVC)值均高于对照组相应指标(P <0. 05);两组不良反应的发生情况间比较差异无统计学意义(P> 0. 05)。结论:在慢性阻塞性肺疾病急性加重期的治疗中联合运用阿奇霉素与阿司匹林,能够提高对患者的治疗效果、改善患者的肺功能。

Objective： To investigate the effect of combined use of azithromycin and aspirin in the treatment of chronic obstructive pulmonary disease during acute exacerbation. Methods： 105 patients with chronic obstructive pulmonary disease with complete treatment information were selected as the subjects of this study. They were divided into control group（ n = 52） and observation group（ n = 53） according to the order of admission. The observation group was treated with aspirin and azithromycin on the basis of conventional treatment,while the control group was treated with conventional treatment. The therapeutic effects of the two groups were observed. Results： The overall effective rate of the observation group was 94. 3 %,which was higher than that of the control group（ 80. 8 %）,and the difference was statistically significant（ P 〈 0. 05）. The forced vital capacity（ FVC）,1 second forced expiratory volume（ FEV1） and FEV1/FVC values of the observers were higher than those of the control group,and the difference was statistically significant（ P 〈 0. 05）. There was no significant difference in the incidence of adverse reactions between the two groups（ P 〉 0. 05）. Conclusion： The combination of azithromycin and aspirin in the treatment of acute exacerbation of chronic obstructive pulmonary disease can improve the patients’ therapeutic effect and improve the patient’s lung function.