系统性红斑狼疮皮疹治疗中糖皮质激素联合羟氯喹的临床价值研究

Study on the Clinical Value of Glucocorticoid Combined with Hydroxychloroquine in the Treatment of SystemicLupusErythematosus

目的:探究糖皮质激素联合羟氯喹治疗系统性红斑狼疮皮疹的临床疗效。方法:将我院2015年11月~2017年11月期间收治的50例系统性红斑狼疮患者随机分为两组各25例。对照组口服醋酸泼尼松片,观察组在醋酸泼尼松片基础上联合使用硫酸羟氯喹片,比较治疗后两组患者临床疗效、补体水平及不良反应情况。结果:(1)观察组临床疗效总有效率92%显著高于对照组80%,两组对比差异有统计学意义(P <0. 05);(2)观察组患者补体C_3、C_4水平略高于对照组,SLEDAI评分低于对照组,两组对比差异明显,有统计学意义(P<0. 05);(3)两组不良反应对比无统计学意义(P> 0. 05)。结论:糖皮质激素联合羟氯喹能有效抑制机体自身免疫反应,加快皮疹消除并能有效修复皮肤皮损,可用于临床治疗SLE皮疹中。

Objective： To investigate the clinical value of glucocorticoid combined with hydroxychloroquine in the treatment of systemiclupuserythematosus. Methods： 50 cases with SLE in our hospital from November 2015 to November 2017 were randomly divided into two groups,25 cases in each group. The control group was given oral prednisoneacetate tablets,and the observation group was given hydroxychloroquinesulfatetablets on the basis of the control group,this paper compares the clinical effect,complement level,adverse reaction condition between the two groups after treatment. Results：（1）Overall clinical effect of the observation group（ 92%） was significantly higher than that of the control group（ 80%）,the difference was statistically significant（ P 〈0. 05）;（2） Complement levels of C3,C4 in the observation group was higher than that in the control group,SLEDAI score was lower than that of the control group,the difference between the two groups was obvious and statistic significant（ P 〈0. 05）;（3） The difference of adverse reaction rate between the two groups had no statistic significance（ P 〉0. 05）. Conclusion： Glucocorticoid combined with hydroxychloroquine can effectively inhibit autoimmune response,quicken erythra elimination,repair skin damage; it can be used in clinical treatment of SLE.