女性灼口综合征患者焦虑、抑郁程度与免疫水平的相关性研究

The correlation analysis among anxiety-depression and immunity in female patients with burning mouth syndrome

目的调查灼口综合征患者焦虑、抑郁情况,探索焦虑、抑郁程度与免疫水平的相关性。方法收集31例女性灼口综合征(burning mouth syndrome,BMS)患者,通过显相焦虑量表(Manifest Anxiety Scale,MAS)、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)以及患者体液免疫和淋巴细胞亚群的检测,分析其焦虑抑郁程度和免疫水平的相关性。结果焦虑组患者Ig E水平低于非焦虑组,辅助性T细胞(CD4+)百分比和CD4+/CD8+比值较对照组降低;抑郁组患者总T淋巴细胞比例低于对照组,自然杀伤细胞(NK细胞)比例高于对照组,差异均有统计学意义(P<0.05)。结论 BMS患者焦虑组与非焦虑组的体液免疫水平、细胞免疫水平存在差异,抑郁组与非抑郁组的细胞免疫水平存在差异。

Objective To investigate the anxiety and depression of the patients with burning mouth syndrome （ BMS）, and explore the relationships among anxiety-depression and immunity, Methods 31 female patients with BMS were investigated by Manifest Anxie- ty Scale （MAS） , Hamilton Depression Scale （HAMD） , humoral immunity and lymphocyte subpopulation tests. The correlation among anxiety-depression and immunity was analyzed. The data were analyzed by SPSS19.0. Results The level of IgE in the anxiety group was lower than the non-anxiety group.The level of Helper T cells （ CD4^＋ ） and ratio of CD4v＋/CD8^＋were lower than the control group. The level of the total lymphocyte in the depression group was lower than the control group, while the level of the natural killer cells was higher. These differences were significant （P〈0.05）. Conclusion The levels of cellular immunity and humoral immunity in anxiety group have differences with those in non-anxiety group.The level of cellular immunity in depression group has differences with that in non-depression group.