母源性印记基因MEG3在肿瘤信号通路中的研究进展

Research Progress of Maternal Imprinting Gene MEG3 in Tumor Signaling Pathways

由于各种组学方法和大数据分析在肿瘤临床样本中的广泛应用,近年来长链非编码RNAs(Long non-coding RNAs,lncRNAs)在肿瘤发生发展中的重要调控作用越来越被广泛认可。母源性印记基因MEG3,在大多数肿瘤中呈低表达,具有抑制肿瘤生长的功能。随着近期研究的不断深入,MEG3在肿瘤细胞中错综复杂分子机制也逐一被不同研究团队所揭示。文章结合近期文献,对肿瘤中MEG3涉及的Wnt/β-catenin、p53、DNA甲基化、pRb等信号通路在参与肿瘤细胞中的增殖、凋亡、迁移、侵袭和耐药等分子机制进行大致系统性阐述,以期为后续信号通路及调控机制的研究提供参考,并为临床应用和其它lncRNAs的研究提供理论基础。

Because of the wide application of various methods and large data analysis in tumor clinical samples,the important regulatory role of long chain non-encoded RNAs（ long non-coding RNAs,lncRNAs） in the development of tumor has been widely recognized in recent years. The MEG3 of mother-derived imprinting gene is low expression in most tumors and has the function of inhibiting tumor growth. With the deepening of recent researches,the intricate molecular mechanisms of MEG3 in tumor cells are revealed by different research teams. In this paper,the involvement of MEG3 in tumors including Wnt/β-catenin,p53,DNA methylation,pRb and other signaling pathways involved in tumor cell proliferation,apoptosis,migration,invasion and drug resistance were systematically expounded in the recent literatures,so that it can act as a reference for the follow-up signal pathway and regulation mechanism,and provide a theoretical basis for the clinical application and other lncRNAs research.