巨噬细胞和神经纤维在子宫内膜异位症中相互作用研究

Interaction between macrophages and nerve fibers in endometriosis

子宫内膜异位症(EMs)是育龄期妇女的常见疾病,但其发病机制目前尚不明确。目前许多研究认为巨噬细胞募集和神经纤维浸润是免疫系统失调在EMs发病机制中的2个主要特征,并且EMs产生的炎性环境与巨噬细胞浸润和神经支配失衡关系密切,但在这个过程中巨噬细胞和神经纤维之间的相互作用仍是未知的,其中巨噬细胞募集和神经形成可能是引起EMs的神经炎性反应和疼痛发病机制。文章对EMs中巨噬细胞和神经纤维的相互作用进行综述。

Endometriosis （EMs） is a common disease in women of childbearing age, but its pathogenesis is still unclear. Many studies have suggested that macrophage recruitment and neurofibrillary infiltration are two major features of immune dysfunction in the pathogenesis of EMs, and the inflammatory environment produced by EMs is closely related to macrophage infiltration and nerve innervation imbalance, but the interaction between macrophages and nerve fibers in this process is still unknown. Macrophage recruitment and neurogenesis may be responsible for the neuroinflammatory response and pain of EMs. The interaction between macrophages and nerve fibers in EMs is reviewed in this paper.