肠系膜组织及其分泌因子在克罗恩病发病中的作用

Role of Mesentery Tissue and its Endocrine Production in Pathogenesis of Crohn's Disease

克罗恩病(CD)的发病机制尚未明确,目前认为与遗传、感染、免疫、内质网应激等方面有关。近年来,肠系膜作为一个完整的器官备受关注,其可能通过脂肪细胞内分泌、参与细菌定植、免疫、改变血流动力学等方面参与CD的发病。本文就肠系膜组织及其分泌因子在CD发病中的作用作一综述。

The pathogenesis of Crohn’s disease （CD） has not been clarified, and it may be related to genetics, infection, immunity, endoplasmic reticulum stress, etc. In recent years, mesentery is considered as a complete organ, which may participate in the pathogenesis of CD through endocrine of adipocytes, involving in bacterial colonization, immunity and hemodynamic changes. This article reviewed the role of mesentery tissue and its endocrine production in the pathogenesis of CD.