自拟攻癌镇痛散联合氯化锶治疗老年恶性肿瘤骨转移性癌痛的临床效果分析

Clinical Effect of Gongaizhentong Powder Combined with Strontium Chloride in the Treatment of Metastatic Bone Cancer Pain in Elderly Patients with Malignant Tumor

目的分析攻癌镇痛散联合氯化锶治疗老年恶性肿瘤骨转移性癌痛的临床效果。方法选取本研究所2015年2月—2016年8月收治的124例老年恶性肿瘤骨转移性癌痛患者,按照治疗方式的不同分为观察组与对照组各62例,观察组采取攻癌镇痛散联合氯化锶治疗,对照组给予唑来膦酸联合氯化锶治疗,对比分析两组临床疗效、疼痛程度、生活质量、镇痛起效时间、疗效持续时间及不良反应发生情况。结果观察组治疗总有效率为91. 94%明显高于对照组的77. 42%,差异有统计学意义(P <0. 05)。治疗后,两组患者疼痛数字分级法评分均降低,行为状态量表评分均升高,且观察组疼痛数字分级法评分降低程度和行为状态量表评分升高程度更为显著,差异均有统计学意义(P <0. 05或P <0. 01)。观察组镇痛起效时间短于对照组,疗效持续时间明显长于对照组,差异均有统计学意义(P <0. 01)。两组不良反应发生率比较差异无统计学意义(P> 0. 05)。结论攻癌镇痛散联合氯化锶治疗老年恶性肿瘤骨转移性癌痛临床效果较好,镇痛起效时间短,可有效提高患者生活质量,且无明显不良反应。

Objective To analyze the clinical effect of Congaizhentong powder combined with strontium chloride in the treatment of metastatic bone cancer pain in elderly patients with malignant tumor. Methods A total of 124 elderly malignant tumor patients with metastatic bone cancer pain admitted to our institute fiom February 2015 to August 2016 were enrolled. According to the different treatment methods, they- were divided into the observation group and the control group, with 62 cases in each group. Patients in the observation group were treated with Congaizhentong powder combined with strontium chloride, and patients in the control group were treated with zole- dronic acid and strontium chloride. The clinical efficacy, pain level, quality- of life, time of onset of analgesia and duration of treatment were compared between the two groups, and the incidence of adverse reactions during the treat- ment was recorded. Results The total effective rate of the observation group was 91.94% , which was significantly higher than that of the control group （77.42%）, and the difference was statistically- significant （ P 〈 0.05 ）. After treatment, both groups of patients had lower scores for pain by digital grading and higher scores by- behavioral status scales. In the observation group, the reduction of scores of pain by- digital grading and an increase in the score bybehavioral status scale were more significant, and there were remarkable difterences （P 〈0.05 or P 〈0.01 ）. The analgesic onset time of the observation group was shorter than that of the control group, and the duration of curative effect was significantlylonger than that of the control group, and the difference was statistically- significant （P 〈 0.01 ）. There was no significant difference in the incidence of adverse reactions between the two groups （ P 〉 0.05 ）. Conclusion The clinical effect of Gongaizhentong powder combined with strontium chloride is favorable in the treatment of metastatic bone cancer pain in elderly patients with malignant tumor, and the analgesic onset time is fast. It can effectively improve the quality of life, with no obvious adverse reactions, therefore, it is the piefeiable choice of treatment in clinical practice.