新生儿胆红素脑病的相关危险因素及其防治措施分析

Correlated Risk Factors and Preventive Measures Analysis on the Incidence of Neonatal Bilirubin Encephalopathy

目的:探讨新生儿胆红素脑病的相关危险因素及其防治措施。方法:选取80例新生儿胆红素脑病患儿作为病例组,同期选择80例无胆红素脑病的新生儿黄疸患儿作为对照组;进行单因素和多因素法来筛选影响新生儿胆红素脑病的相关危险因素。结果:多因素Logistic回归分析结果显示,新生儿胆红素脑病的危险因素包括总胆红素峰值(OR=5. 083)、感染(OR=4. 200)、新生儿溶血(OR=3. 452)、代谢性酸中毒(OR=3. 028)、12h内黄疸(OR=2. 465)等。结论:新生儿胆红素脑病的高危因素包括总胆红素峰值偏高、感染、新生儿溶血、代谢性酸中毒、出生12h内出现黄疸;应针对这些高危因素,早预防、早治疗新生儿胆红素脑病,降低胆红素脑病对患儿的危害。

[Objective] To explore the correlated risk factors and preventive measures of neonatal bilirubin encephalopathy. [Method]80 cases of neonatal bilirubin encephalopathy w ere chosen as study group,and the other 80 cases of icterus neonatorum w ithout bilirubin encephalopathy w ere considered as control group. The correlated risk factors of neonatal bilirubin encephalopathy w ere screened by single factor and multiple factors methods. [Result] M ultiple factors Logistic regression analysis result show ed that the risk factors of neonatal bilirubin encephalopathy included in jaundice in total bilirubin peak（ OR = 5. 083）,infection（ OR = 4. 200）,hemolysis of the new born（ OR = 3. 452）,metabolic acidosis（ OR = 3. 028） and 12 h（ OR = 2. 465）. [Conclusion] The high risk factors of neonatal bilirubin encephalopathy contain peak value of total bilirubin,infection,metabolic acidosis,neonatal hemolysis and jaundice in 12 h. To aim directly at these above high risk factors,w e should early prevent and treat neonatal bilirubin encephalopathy,to reduce the harm of bilirubin encephalopathy to children.