铝碳酸镁联合维生素B6治疗妊娠剧吐的疗效和安全性评价

The Efficacy and Safety Evaluation of Hydrotalcite Combined with Vitamin B6 in Treatment of Hyperemesis Gravidarum

目的:探讨铝碳酸镁联合维生素B6治疗妊娠剧吐的临床疗效和安全性。方法:101例妊娠剧吐患者按治疗方案分为2组。对照组给予维生素B6和静脉补液,治疗组在对照组的基础上嚼服铝碳酸镁,比较2组疗效、不良反应和妊娠结局。结果:治疗组患者治疗有效(95. 24%),高于对照组患者(84. 75%),差异有统计学意义(P <0. 05)。治疗组患者呕吐症状消失时间、酮体转阴时间、电解质恢复正常时间、输液时间均短于对照组,用药后妊娠呕吐评分低于对照组,差异有统计学意义(P <0. 05)。2组患者不良反应发生情况和妊娠结局差异无统计学意义(P> 0. 05)。结论:铝碳酸镁联合维生素B6治疗妊娠剧吐效果显著,妊娠期使用相对安全,值得临床推广。

[Objective] To investigate the therapeutic effect and safety evaluation of hydrotalcite combined with vitamin B6 on hyperemesis gravidarum. [Method] 101 hyperemesis gravidarum patients w ere divided into control group and treatment group according to the treatment plan. The control group w as given vitamin B6 w ith venous rehydration,and the treatment group w as chew ed Hydrotalcite tablets on the basis of the control group. The efficacy,adverse reactions and pregnancy outcome of the tw o groups w ere compared. [Result] The effective rate in the treatment group（ 95.24%） w as higher than that in the control group（ 84. 75%）,and the difference w as statistically significant（ P〈0. 05）.In treatment group,time of vomiting symptoms disappeared. Ketone body transition,electrolyte returned to normal and infusion duration w as shorter than that of the control group. The average vomiting score after treatment w as less than that of the control group. All the above difference w as statistically significant（ P〈0. 05）. [Conclusion] Oral hydrotalcite combined w ith vitamin B6 in the treatment of hyperemesis gravidarum patients w ith significant effect. It is relatively safe and w orthy of promotion.