丙型肝炎病毒耐药相关变异对直接抗病毒药物疗效的影响

Effects of hepatitis C virus resistance associated variants on the efficacy of direct-acting antiviral agents

随着直接抗病毒药物的不断更新与广泛应用,慢性丙型肝炎的治愈率显著提高。丙型肝炎病毒耐药相关变异直接影响抗病毒疗效和获得病毒学治愈的机会,已越来越受到关注。本文就丙型肝炎病毒耐药相关变异对直接抗病毒药物疗效的影响进行综述,以便更好地治疗丙型肝炎。

Along with the continuous renewal and wide use of direct-acting antiviral agents, the cure rate of chronic hepatitis C improved obviously. However, the resistance associated variants as well as their rapid emergence during incomplete drug-pressure greatly affect treatment outcome and the chances of virological cure. In this paper, the effects of drug resistance of hepatitis C virus on the efficacy of direct-acting antiviral agents were reviewed to facilitate better treatment on hepatitis C.